Neural Therapies

About Neural Therapies

Neural Therapies is a Contract Research Organisation (CRO) specialised in the analysis of the effect of drug candidates and/or nutraceuticals in preclinical rodent models of stroke and Alzheimer’s Disease. A customized analysis of the damage extension, different cell death pathways, homeostatic and/or behavioural response can be performed, assessed by a panel of experts to optimize costs and assays. Additional services extensive to other pathologies have been added to our portfolio. These services include toxicological analysis, immunofluorescence and confocal microscopy assays as well as stereology services. Located in Leon, Spain, Neural Therapies provides a cost-effective service, offering cutting-edge technology at reasonable price, and customizing each assay according to the client's need or request. Services Our technical skills and deep knowledge in biomedical research grant a customized design for each project to satisfy our customer needs. The main services included in our portfolio are: 1.- Molecule screening in the following stroke models: a. Middle cerebral artery occlusion (MCAO) model b. 2-vessel occlusion (2VO) model c. Oxygen and glucose deprivation (OGD) in organotypic hippocampal cultures Evaluation of the molecule effects includes infarct volume, behavioural response, astroglia/microglia dynamics and homeostatic pathways according to customer’s needs. 2.- Molecule screening in the following Alzheimer’s Disease models: a. PS1delta9 x APPlondon (PS1/APP) transgenic mice. Evaluation of the molecule effects includes beta-amyloid deposits, tau protein phosphorylation, neuroinflammation and behavioural analysis. 3.- Toxicological analyses in rodents: Evaluation of the toxic effects of the molecule includes number of blood cells, serum analysis of ALT, AST, CK and urea and collection and/or histopathological analysis of organs selected by the customer. 4.- Confocal microscopy-based analyses.

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